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In the STEP 4 trial and subsequent research, patients who stopped GLP-1 therapy without maintaining an exercise habit regained an average of 9.6 kilograms within one year

Expert consensus from major diabetes and obesity societies recommends against combining these substances without explicit provider oversight

Research in the Rinaman laboratory was funded by the U.S

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In preclinical research, this combination is investigated for its potential multi-target approach to complex tissue healing

STEP UP Phase 3 Trial Design The sNDA incorporates data from the STEP UP trial (NCT05646706), a 72-week, randomized, double-blind, placebo- and active-controlled superiority study involving 1,407 adults with obesity (BMI 30 kg/m)