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Final Thoughts Retatrutides Phase 3 TRIUMPH-4 results may represent a defining moment for the obesity and peptide therapeutics landscape

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Genetic Predisposition to Fat Storage and GLP-1 Response Individual differences in weight management ability stem partly from genetic variation in appetite-control and lipid-metabolism genes

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Comparison Between Weight Loss Surgery vs GLP-1s Weight Loss Outcomes The difference in outcomes is very apparent when GLP-1s are compared to bariatric surgery , the latter leads to 23-35% total body weight loss and patients are able to maintain these results with healthy routines and good diets for decades, whereas GLP-1s deliver around 10-15% weight loss and can only be maintained with constant doses over a period of time

It may be that trials of future agents in these classes might consider containing arms with patients on combinations of agents