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A 2024 retrospective study published in the Annals of Dermatology found that women and older adults are particularly susceptible to weight-loss-induced telogen effluvium, even when the degree of weight loss is not more severe than in other groups

Specifically, TMAO enhances cardiac sympathetic activity through both direct (left stellate ganglion) and indirect (central autonomic) pathways, while concurrently upregulating pro-inflammatory cytokine release

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These treatments may help people lose weight and control certain health problems more effectively than with diet and exercise alone

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