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Pooled and combined analyses Only five33 34 40 91 92 of the clinical trials above, all of which had shown a significantly positive effect of various GLP-1RAs on cognition, were comprised in a meta-analysis including 7732 individuals with T2DM, which however unexpectedly did not observe a benefit on cognitive scores (SMD 0.33
Tirzepatide is a once-weekly subcutaneous injection approved by the FDA for the treatment of type 2 diabetes mellitus (Mounjaro) and chronic weight management (Zepbound)
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