A cooperative role of NRF2 and C/EBP (a transcription factor of the CCAAT/enhancer binding protein family) was described in generating tumor-specific enhancers that promote tumor initiation via NOTCH3 activation (Okazaki et al, 2020)
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The study revealed that SFN supplementation significantly modulated gene expression profiles in prostate tissue, with upregulation of genes involved in carcinogen detoxification and downregulation of genes associated with cancer progression pathways
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