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Retatrutide (LY3437943) is an investigational triple hormone receptor agonist that activates: GLP-1 (glucagon-like peptide-1) receptor GIP (glucose-dependent insulinotropic polypeptide) receptor Glucagon (GCG) receptor This triple G mechanism targets multiple pathways for appetite control, insulin sensitivity, glucose regulation, and energy/fat metabolismpotentially offering greater effects than dual (GLP-1/GIP) or single agonists
A history of pancreatitis, as GLP-1s can, in rare cases, cause this condition, which often presents with severe abdominal pain
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It typically starts at the lowest dosage, which is gradually increased as the patient adjusts to the medication and tolerates its potential side effects
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