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Acknowledgments The authors would like to express their sincere gratitude to Hao Wang, Cankun Zhou, Yonglian Chen, Jun Lyu, Minqing Feng, and Xiaobin Huang for their valuable contributions to the early stages of this work and for their collaborative support throughout the research process

Subgroup analyses by sex and age showed consistent results

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The levels of CB1 and CB2 increase in the synovial membrane with RA

LPS + l-carnitine + Compound C: Compound C pretreatment at 10 M for 12 h in LPS-treated FLS, and 2.5 mM l-carnitine was administered for 24 h