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In fasted states, including ALS, skeletal muscles increase utilization of fatty acid oxidation, which in turn reduces glucose metabolism [304, 305]

PMID: 20388964 Sikiric P, Seiwerth S, Mise S, et al

doi: 10.1093/toxsci/51.2.161

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Although direct evidence for GLP-1RA use in PsA remains limited, the inclusion of PsA populations in these tirzepatide trials represents a conceptual shift toward testing immunometabolic interventions in inflammatory arthritis rather than restricting their evaluation to skin disease alone

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