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Description

20,21 In this approach, androgenetic haploid embryonic stem cells (AG-haESCs) with deletions in the differentially methylated regions of the imprinted loci H19 -DMR and IG -DMR (termed DKO-AG-haESCs) are injected into the oocyte cytoplasm to efficiently produce gene-modified animals, referred to as semi-cloned mice

Xie J, Chen X, Zheng J, Li C, Stacy S, Holzenberger M, et al