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This dual mechanism is the pharmacological reason tirzepatide produces greater average weight loss than GLP-1 single-agonists in clinical trial data
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Ipamorelin is a growth hormone secretagogue and selective ghrelin receptor agonist
OS can activate the NLRP3 inflammasome, triggering caspase-1 activation and pyroptosis (Won et al., 2015)
A progressive decrease in body weight was also observed for up to 3 years in exenatide-treated patients [46,48]
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