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The introduction of the R17 Cagri- E14 Cagri intra-peptide ionic lock energetically favours the formation of a predominant bypass conformation at the CTR, which, together with the P37 substitution and the effects induced by the N-terminal acylation, likely underlies its improved potency over rAmy at this receptor

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The randomization to sequences was stratified by sex and performed dynamically by the minimization technique using the dynamic allocation algorithm, second-best probability set to 15%, with the help of the Medidata-RTSM software

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Oxidized glutathione (GSSG) has already done its job