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Pettus J, Boeder SC, Christiansen MP et al (2022) Glucagon receptor antagonist volagidemab in type 1 diabetes: a 12-week, randomized, double-blind, phase 2 trial
During the overlap period, they are effectively on both medications
Major adverse cardiovascular event (MACE) reduction in patients with type 2 diabetes with established cardiovascular disease has been firmly established in landmark cardiovascular outcomes trials such as LEADER (Liraglutide Effect and Action in Diabetes: Evaluation of Cardiovascular Outcome Results), SUSTAIN-6 (Semaglutide in Subjects with Type 2 Diabetes), and REWIND (Researching Cardiovascular Events with a Weekly Incretin in Diabetes)
An RCT was included in the analysis if it examined at least one of the biomarkers, including waist circumference, blood pressure, FBS, TG, or HDLc
