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We and others also demonstrated that hemin induces the expression of NRF2 in SCD erythroblasts and animal models and such effect is mitigated by administration of dimethyl fumarate (DMF) 23,24 , an FDA-approved drug for the treatment of multiple sclerosis

[PMID: 29891966] PubMed record related to this compound for laboratory literature review

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When prescribed by a healthcare professional, it is safe based on diagnostics like body composition, and health history

Next, to further investigate the role of Trim37 in PGCs in vivo, we first generated Blimp1-T2A-Cre knock-in mice and validated Cre-mediated loxP recombination in gonads using Rainbow mice 29 (Supplementary information, Fig

Motivational performance was measured by the Monetary Incentive Delay Task coupled to a physical effort after 14 days and 28 days of supplementation