Additionally, A1AT inhibits the activity of inflammatory molecules such as IL-8, TNF-, and NE
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That is, it loves to neutralize free radicals
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iNOS-produced NO induces LES relaxation leading to the development of GERD, and in a mouse model of sepsis infected with lipopolysaccharides, the LES releases INOS causing impaired LES contraction, which can be blocked by utilizing NOS inhibitors (58)
105 Although this is not generalizable to other cancer patients, especially those at risk for malnourishment, IF and STS could be considered as therapeutic options in such cases