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Arginine is formed from proline catalyzed by arginine synthase and can be oxidized by nitric oxide synthase to citrulline, which is then hydrolyzed to ornithine

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Distribution and uptake studies revealed distinct internalization of Cy5-labelled MPH NPs by LPS-stimulated RAW 264.7 cells (CD44-expressing) (Vachon et al., 2006) compared to NIH 3T3 (non-CD44-expressing) (Rios de la Rosa et al., 2017) cells, suggesting specific binding affinity of MPH NPs to CD44-positive cells ( Figure 6D )

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Of interest, treatment with TZT increases the expression of insulin-like growth factor (IGF) levels and associated binding proteins IGFBP1 and IGFBP2 (Thomas et al

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V.LiuS.SoongY.MillsW.SinghP.WarrenJ

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