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Additionally, use of proton pump inhibitors (PPIs) and diuretics (or "water pills") such as furosemide and hydrochlorothiazide can lead to magnesium deficiency over time

Ghosh M, Jana A, Sinha S, Jothiramajayam M, Nag A, Chakraborty A, Mukherjee A (2016) Effects of ZnO nanoparticles in plants: cytotoxicity, genotoxicity, deregulation of antioxidant defenses, and cell-cycle arrest

Although essential for maintaining intestinal homeostasis, dysregulated inflammasome activity is a key driver in the pathogenesis of chronic IBD

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Thus, we hypothesize that the water molecule can act as a possible nucleophile to attack the H-site bound GSH and generate GS