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D.WangS.AnuarF.QianY.BjrkholmB.SamuelssonA.et al

Pre-dosing with 2550mg diphenhydramine (Benadryl) 30 minutes before injection blunts histamine-mediated flushing and reduces nausea by approximately 40% in clinical observation, though this adds drowsiness that may interfere with morning productivity

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The GLP-1 agonists used were liraglutide (57.3%), followed by semaglutide (32.9%), dulaglutide (4.9%), exenatide (4.1%), and lixisenatide (0.9%)