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In addition, nausea is believed to result mainly from central mechanisms, in which activation of GLP-1R neurons in the area postrema plays a predominant role rather than from delayed gastric emptying alone 46

Glucagon promotes hepatic glycogenolysis, stimulates gluconeogenesis, and critically, increases energy expenditure and thermogenesis

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diarrhoea arises from altered gut motility, bile acid metabolism, and microbiota changes

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