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This is where GLP-1-based therapies come into play

From a receptor pharmacology perspective, GLP-1 receptor agonists act through GLP-1R activation, a class B G-protein-coupled receptor signaling system with established systemic effects on appetite regulation, gastric emptying, glucose-dependent insulin secretion, metabolic control, and weight reduction (Drucker, 2025)

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Ipamorelin may be preferred for targeted benefits, while Sermorelin is better for long-term, steady GH support and anti-aging effects

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