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By fusing the active GLP-1 (7-36) fragment to the N-terminus of TB01-2s light chain, they developed TB59-2
GLP-1 therapy for type 2 diabetes helps improve blood sugar control, reduce insulin resistance, promote weight loss, and lower cardiovascular risk
How they work Alli and Xenical work to promote weight loss by blocking an enzyme called lipase
ARC GABAergic neurons that express thyrotropin-releasing hormone (TRH), approximately 60% of which expressed GLP-1R, were found to have GABAergic afferents directly targeting AgRP neurons
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