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Regarding safety profile, in phase 2 trials for obesity and diabetes, mazdutide was discontinued due to AE by 02% of participants and SAE experienced by up to 7% of participants with mazdutide 6 mg (Tables 2 and 3)
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This enzyme not only exhibits phosphatase activity, dephosphorylating thiamine phosphates in the lumen, but may also transphosphorylate extracellular thiamine to intracellular thiamine monophosphate (ThMP), at the expense of intracellular phosphate donors such as beta-glycerophosphate or creatine phosphate (101)
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