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Jespersen MJ, Knop FK, Christensen M

The biologic effects of IGFs signaling on cancer Once activated by the ligands, IGF-IR and InsR may initiate diverse signaling pathways to regulate cell proliferation, differentiation, survival, metabolism, migration, and stemness (Fig

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However, lactate production is increased in hemocytes (9, 10), suggesting increased ATP production by glycolysis, which is much less efficient (2 ATP per glucose molecule) and consequently requires more glucose

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