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Health technology assessment bodies require demonstration of value beyond statistical efficacy, including durability of effect, quality-of-life improvement, and reduction in downstream healthcare costs
& Sanz, A
10.3390/ijms18112493 192
The glycemic improvements were equally impressive, with 73.5% of combination participants achieving HbA1c levels at or below 6.5%
Long-term plan: how would weight regain and monitoring be handled
In a yearlong Phase 3 trial, the highest dose of Lilys pill, orforglipron, lowered a measure of blood sugar called A1C by 1.9 percentage points, while the highest dose of Novos drug, marketed as Rybelsus, lowered A1C by 1.5 percentage points, when analyzing all patients regardless of discontinuations
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