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Mice were placed onto a cage hopper and infused with semaglutide, GLP-1MK-801 or vehicle (isotonic saline) over 60 s at a total infusion volume of 2 l through a Hamilton syringe mounted onto an automated syringe pump (Harvard Apparatus) and a 33-gauge internal cannula (PlasticsOne, C315IS-4/SPC, 2.5 mm)

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They also note that when the body is low on fluids, it can hold onto excessive sodium, which can cause bloating and water retention

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However, there is currently no available data assessing the efficacy of these medications specifically for the treatment of BED