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Early improvements may include reduced discomfort and better digestion, while deeper structural repair develops over several weeks of consistent use

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To put that into perspective: Many participants also experienced improvements in: Waist circumference Blood pressure Cholesterol levels Blood sugar control Overall metabolic health Importantly, individual results can vary significantly depending on factors such as diet, exercise habits, medication adherence, sleep quality, and underlying health conditions

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One person commented saying, "The fact she uses dibetic [sic] medication to get this skinny is disturbing," Buzzfeed reported

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The proportion of patients who completed treatment with rescue medication varied across trials, but was consistently lower with oral semaglutide 7 mg, 14 mg, and flexibly dosed (026% across background medication subgroups) than comparator treatments (734%), whereas the proportion of patients who discontinued the trial product was often somewhat higher (1225% vs 515% except when sitagliptin was added to multiple background medications in PIONEER 7 [50% in a very small subgroup of 8 patients]) (see Table S1 in the Supplementary Information)

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