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These lawsuits allege that the drug has caused serious side effects such as pancreatic inflammation, thyroid cancer, kidney failure, and gastrointestinal issues, including stomach paralysis, which Novo Nordisk failed to warn patients about
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doi: 10.1016/j.mad.2016.12.005 209 KlingeCM
This extension not only increased the molecular weight (from 7.6 kDa to 9.1 kDa), but also reduced the affinity for IGF binding proteins (IGFBPs) through steric hindrance effect