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Drugs for weight loss, including GLP-1s, are among the rare exceptions
Colonic epithelial cell-specific knockdown of the FASN gene significantly inhibits Mucin 2 (MUC2) palmitoylation, leading to impaired mucus secretion, abnormal intestinal barrier permeability, and flora-immunity imbalance, which eventually may induce colitis and systemic inflammatory response (145)
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Maternal total sleep deprivation causes oxidative stress and mitochondrial dysfunction in oocytes associated with fertility decline in mice
a trial is underway assessing whether tirzepatide lowers major cardiovascular events in people with Type 2 diabetes
Patients with a personal or family history of MTC or MEN2 should not receive these medications
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