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The combined effect of these pathways creates a coordinated signaling response in which cAMP-dependent transcriptional activity and calcium-mediated secretion processes converge
Funding This work was financially supported by the National Natural Science Foundation of China (82405190), the Sichuan Science and Technology Program (2024NSFSC1819), the University-level Project of Southwest Medical University (2023ZYYQ05), and the Luzhou Science and Technology Program (2022-JYJ-136)
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Instillation of ophthalmic formulation containing nilvadipine nanocrystals attenuates lens opacification in shumiya cataract rats
These observations imply that ROS function not simply as indicators of oxidative stress during treatment, but also may converge on specific signaling nodessuch as DNA damage response pathways, kinase networks, and mitochondrial remodelingto stabilize drug-resistant cellular states ( Figure 3 )
Wechter, M
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