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Over time, the body develops some tolerance to the gastric slowing effect, so their gastric emptying delay is less acute (and thus they have milder postprandial effect relative to short-acting ones) ( [112] ) ( [113] )

Trulicity starting dose is 0.75 mg once weekly for the first month, which can be increased to 1.5 mg in the second month, and further increased in 1.5 mg increments up to a maximum dose of 4.5 mg weekly based on therapeutic response

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[PMID: 29541331] PubMed record related to this compound for laboratory literature review

Despite their shared mechanism of action, GLP-1RAs differ pharmacologically in terms of their molecular structures (e.g., lipidation or adding lactam bridges), pharmacokinetics (e.g