Obesity is a chronic disease with chronic metabolic, hormonal, and neurological drivers
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Other factors may also impact differences such as age, source of mice, animal facility temperature, diet, and the microbiome which have demonstrated impacts on both obesity and cancer 29
[5] [6] Pancreatitis has been reported with GLP-1 medications
A study of ME/CFS by Akiko Iwasaki and colleagues, using plasma and CSF samples of affected individuals and matched controls, demonstrated 2 distinct immunotypes for this condition, which is characterized by many symptoms that are referable to the central nervous system
But biological plausibility is not the same as clinical proof