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Various signalling cascades, such as PI3K/Akt/mTOR, MAPK/ERK, Wnt/-catenin, the NF-B pathway, JAK/STAT pathway, and TGF- cytokine signalling, collaborate to orchestrate the proliferation, survival, invasion, and metastatic proficiency of malignant cells
Epigallocatechin gallate, a polyphenolic component of green tea, inhibits the progression of various cancers, including glioma, breast and liver cancers, by inhibiting IGF-1R via the phosphorylation of the tyrosine kinase IGF-1R (118120)
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