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Third, the included studies consisted mostly of mixed prior and non-prior ASCVD patients, preventing a direct comparison of the utility of GLP-1RA between primary and secondary prevention cohorts

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In various clinical trials, doses ranging from 250 mg to 1,000 mg per day have been used without significant adverse events

Cell culture Baby hamster kidney (BHK) cells stably over-expressing human, cynomolgus, rat, mouse and pig GLP-1 receptor, human glucagon receptor, human GIP receptor, human GLP-2 receptor or co-expressing hGLP-1R and cAMP response element (CRE) coupled to firefly luciferase (CRE luciferase) were generated at Novo Nordisk A/S