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In the field of prescription medications, most medications that small uncontrolled studies have suggested may have some positive effects are later shown to not have significant positive outcomes after being tested in the much larger, more rigorous studies required to attain FDA approval

I feel like although the earlier commenters made it out like it's so 'uncommon', it's not at all

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2020 Oct-Dec;15(4):365-369

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The timeline for peak results in these tissues is 4 to 6 months of consistent protocol adherence, not the 4-week improvements some internet resources suggest