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Self-Administration Ban: This is a specialized clinical injection

doi: 10.1038/s41587-019-0209-9 21 BradshawE.AlejmiA.RossettiG.DAvossaG.MacdonaldJ

REDEFINE 1 enrolled 3,400 adults with obesity but no diabetes

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Most common adverse events at all doses: Nausea (3355%, dose-related) Vomiting (1335%) Decreased appetite (1528%) Constipation or diarrhea (1020%) Injection-site reaction (510%) Dose-related dysesthesia signal: The TRIUMPH-4 trial identified a dose-related dysesthesia (nerve-tingling, paresthesia) signal: This is the most-flagged trial-level safety signal for retatrutide and the reason community doses cluster at 2-4 mg/week well below where the dysesthesia signal becomes prominent

This type used to be called ADD, which is now an outdated term