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Common side effects of semaglutide are usually mild and may include: Nausea Vomiting Diarrhea Constipation Abdominal pain Decreased appetite Indigestion The majority of side effects are transient and typically resolve spontaneously
One study involving 150 women with PCOS and impaired glucose regulation found that combining a GLP-1 receptor agonist with metformin resulted in a 64% remission rate of prediabetes
J Family Med Prim Care 10(12):4418 Prasad-Reddy L, Isaacs D (2015) A clinical review of GLP-1 receptor agonists: efficacy and safety in diabetes and beyond
Switching medications does not eliminate these underlying risks
The peptides primary target is the GHRH receptor, not an adipose-tissue receptor
9 Studies examining body composition changes during GLP-1 therapy have reported a range of results regarding lean mass loss
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