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The development of further dual GLP-1/GIP receptor agonists seems to be a promising next step in managing various cardiovascular disease

An independent external adjudication committee (EAC) validated prespecified categories of adverse events (including deaths, selected cardiovascular events, malignant neoplasms, thyroid diseases [malignant thyroid neoplasms and C-cell hyperplasia], acute kidney injury, acute pancreatitis, and lactic acidosis) except in SUSTAIN 10 where there was no adjudication

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However, individual tolerability and safety to GLP-1RA may vary due to differences in molecular structures (77)