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However, with inverse variance weighted Mendelian randomization, no causal relationship between serum vitamin C levels and MASLD risk was observed (OR = 0.82, p = 0.502)

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Vitamin B12 deficiency may develop with long-term metformin use (affecting 10-30% of users), warranting periodic monitoring (every 2-3 years), particularly in patients with anemia or neuropathy symptoms

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