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Data from clinical studies In an observational study involving 20 diabetic subjects receiving background metformin therapy, exenatide treatment over 16 weeks resulted in improved flow-mediated vasodilation of the brachial artery following 5 min of forearm ischemia, as assessed by ultrasound echocardiography, compared to patients treated with glimepiride [85]

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The extracellular parts of TM1 and TM2 moved inward to the center, while TM7 moved outwards accompanied by conformational changes of ECL1

Sin embargo, a diferencia de los genricos qumicos que son idnticos al original, los biosimilares requieren estudios clnicos propios para demostrar que funcionan igual, lo que retrasa su llegada al mercado incluso despus del vencimiento de patentes