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Metabolic interactions : Berberine's effects on glucose metabolism, combined with phentermine's metabolic stimulation and appetite suppression, could theoretically lead to blood sugar lowering, particularly in individuals taking antidiabetic medications or markedly restricting caloric intake
Methylfolate is the only metabolite of folate that can cross the blood-brain barrier, and plays a key role in cell metabolism, protein methylation, and the synthesis of the monoamine neurotransmitters
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This was because the function of GIP in the pathophysiology of diabetes was historically questionable
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