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PMCID: PMC9624240 DOI: 10.1161/CIRCULATIONAHA.122.061732 Packer M (2023): SGLT2 inhibitors: role in protective reprogramming of cardiac nutrient transport and metabolism

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The combination of mechanical unloading and direct cartilage protection is a powerful one-two punch that has a lot of orthopedic surgeons paying very close attention right now

In addition to renal outcomes, SGLT2 inhibitors also contribute to modest weight loss and blood pressure reduction

High costs, as well as tolerability issues, remain considerable barriers to a more wide-ranging prescribing of these drugs 1

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