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Individuals who are pregnant, breastfeeding or have underlying medical conditions should consult a healthcare professional before use
SHP is involved in bile acids synthesis by downregulating the gene transcription of cholesterol 7 alpha-hydroxylase (CYP7A1), a rate-limiting enzyme in bile acid synthesis
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Supplements do show promise, but relying solely on them without addressing other lifestyle factors may produce limited results
This work was supported by the following grants awarded to O.M.: the Israel Innovation Authority Kamin grant 62615, the German-Israeli Foundation for Scientific Research and Development grant 1412-414.13/2017, the ICRF professorship grant, the ISF Israel-China grant 2554/18, the MOST-DKFZ grant 3-14931, and the Ministry of Science and Technology grant 3-14764
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