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Unlike current GLP-1 receptor agonists such as semaglutide (Ozempic, Wegovy), Retatrutide is a triple hormone receptor agonistactivating GLP-1, GIP, and glucagon receptors simultaneously

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Retatrutide inhibits appetite and promotes insulin secretion by activating the GLP-1R, improves insulin efficiency and enhances energy utilization by activating the GIP receptor, and simultaneously stimulates fat oxidation and energy consumption by activating the glucagon (GCG) receptor

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