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Daily Medication Pearl: Semaglutide (Rybelsus) for Diabetes Saro Arakelians, PharmD Semaglutide acts as a GLP-1 receptor agonist that selectively binds to and activates the GLP-1 receptor

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Oral semaglutide was superior to placebo and other antihyperglycemic drugs, such as iDPP4 (sitagliptin), iSGLT2 (empagliflozin) or other arGLP-1 (liraglutide) in reducing HbA1c or weight.116 Oral semaglutide was well tolerated, with a safety profile similar to that of other arGLP-1 s