Start with a moderate dose, listen to your body, and dont hesitate to seek professional guidance.
The research, which examined data from four of the five Semaglutide Treatment Effect in People with obesity (STEP) trials, looked for changes in symptoms of depression using the Patient Health Questionnaire-9 (PHQ-9), and for indications of potential suicidal ideation and behavior using the Columbia Suicide Severity Rating Scale
This is due, in part, to high rates of aerobic metabolism, particularly in the proximal tubules
The FDA has documented adverse-event reports involving compounded semaglutide and tirzepatide, including dosing errors, gastrointestinal events requiring medical attention, and cases where cold-chain failures affected medication stability during shipping
nice.org.uk/guidance/ta1026/resources MHRA
It is not yet a confirmed answer