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For example, studies conducted in murine b.End.3 endothelial cells have shown that hyperglycemia influences redox enzymes and oxidative stress, inducing the activation of proinflammatory signaling pathways NF-B, c-Jun N-terminal kinase (JNK), extracellular signal-regulated kinase (ERK), and phosphoinositide 3-kinase (PI3K) (Arcambal et al., 2019)

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10.1021/acscentsci.0c00397 50 NieT.ZouW.MengZ.WangL.YingT.CaiX.et al (2022)