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We found that, as with folate deficiency (which may effectively alter methylation reactions and deoxyribonucleotide biosynthesis), methionine loading (which maintains an efficient transmethylation pathway) promotes the occurrence of an oxidant stress-mediated prethrombotic state that is correlated with total plasma homocysteine concentration (Durand et al, 1997a
Colivicchi, F., Bassi, A., Santini, M
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Liver dysfunction occurs in 32% of patients with ALT elevation up to 311 IU/L compared to the normal range of 10-40 IU/L
