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Given that this drug affects blood pressure and other systems, medical supervision is important for safe use
10.1038/s41568-020-00320-2 9 BluherM
Barkley restarted treatment with Ro to hit his weight loss goal
The agency permits some unapproved drugs to be marketed if they are relied on by health care professionals to treat serious medical conditions when there is no FDA-approved drug to treat the condition or there is insufficient supply of FDA-approved drugs. Given these complexities, ideal patient candidates for Retatrutide include individuals with significant obesity, persistent insulin resistance, and metabolic syndrome who have not adequately responded to other medically supervised weight-loss strategies and who clearly understand the investigational status of the medication
Consequently, clinicians are advised to consider protocol adjustments, such as extended fasting periods and alternative bowel preparation regimens, to optimize endoscopic outcomes and minimize risks in patients on GLP-1 therapy
Studies have also reported modest effects on energy expenditure
