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Simpson said people with active cancer or a history of tumors are especially at risk

Fluid retention and edema: During treatment with glucocorticoids and diclofenac, edema and fluid retention have been observed so the formula must be used with caution in patients with a history of decompensation, hypertension or other factors predisposing to fluid retention

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Difficulty concentrating and impaired memory: These may indicate a Vitamin B12 deficiency, which can also lead to mental health issues like depression and behavioral changes

It also decreases the incidence of active colitis

These ranges reflect what produced measurable effects in rodent models under controlled conditions