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The most serious risk, lactic acidosis, is extremely rare (estimated at 1-5 cases per 100,000 patient-years) and occurs almost exclusively in patients with severe kidney impairment or acute illness

Methylation contributes to the bodys natural detoxification processes by supporting the metabolism and elimination of a variety of compounds

Thus, it acts as a buffer by inhibiting the accumulation of lactic acid in the muscles, which helps delay fatigue and prevent cramping

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PubMed laboratory research record [PMID: 22655244] PubMed record related to this compound for laboratory literature review

The morning surge was defined as the difference between the morning pressure during the first 2 h after awakening and the average of the lowest nighttime BP