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This BBB dysfunction in PD is linked to the degeneration of dopaminergic neurons, which release alpha-synuclein (Syn) into the brain parenchyma, exacerbating BBB dysfunction (Fig

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Importantly, stem cells play a repairing role by migrating to the injured sites, inducing directional differentiation, eliciting paracrine effect and modulating the immune response

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The most common side effects reported by the MHRA for semaglutide tablets are gastrointestinal: nausea, diarrhoea, constipation and vomiting